Triethylamine → HCID 58372758, compound

HRID 656758Notes

Reaction equation

HRID 656758 reaction equation
[CH3:1][O:2][C:3](=[O:27])[CH2:4][C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[C:7]([O:12][C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][C:14]=2[CH2:20][S:21][CH2:22][C:23]([F:26])([F:25])[F:24])[CH:6]=1.C(N(CC)CC)C.[C:35](Cl)(=[O:40])[C:36]([CH3:39])([CH3:38])[CH3:37]>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:27])[CH2:4][C:5]1[CH:6]=[C:7]([O:12][C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:35](=[O:40])[C:36]([CH3:39])([CH3:38])[CH3:37])=[CH:15][C:14]=2[CH2:20][S:21][CH2:22][C:23]([F:25])([F:26])[F:24])[CH:8]=[C:9]([Cl:11])[CH:10]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62493Pivaloyl chlorideHCID 58372742HCID 58372742, compound

Product 1

HCID 58372758HCID 58372758, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of {3-[4-amino-2-(2,2,2-trifluoro-ethylsulfanylmethyl)-phenoxy]-5-chloro-phenyl}-acetic acid methyl ester (0.058 g, 0.14 mmol) in CH2Cl2 (2 mL) was added triethylamine (0.04 mL, 0.28 mmol), followed by pivaloyl chloride (0.02 mL, 0.17 mmol), and the reaction was stirred at room temperature for 10 minutes. After work-up with CH2Cl2 and H2O, the crude material was purified by silica gel chromatography to give the title compound.

Workup

  1. customAfter work-up with CH2Cl2 and H2O, the crude material was purified by silica gel chromatography

Sources & evidence

ORD record
ord-6a027328c89344378139f502e377e4c5
Source dataset
uspto-grants-2011_12
Patent number
US08071807B2

Reaction notes

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