Lithium Hydroxide → HCID 44599160, compound

HRID 656770Notes

Reaction equation

HRID 656770 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:27])[NH:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:17][C:16]=2[CH2:28][S:29][C:30]([CH3:33])([CH3:32])[CH3:31])[CH:7]=1)C.[OH-].[Li+]>CO.O>[C:23]([NH:22][C:21]([C:18]1[CH:19]=[CH:20][C:15]([O:14][C:8]2[CH:7]=[C:6]([CH2:5][C:4]([OH:34])=[O:3])[CH:11]=[CH:10][C:9]=2[O:12][CH3:13])=[C:16]([CH2:28][S:29][C:30]([CH3:33])([CH3:32])[CH3:31])[CH:17]=1)=[O:27])([CH3:25])([CH3:26])[CH3:24]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58372803HCID 58372803, compound

Product 1

HCID 44599160HCID 44599160, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

[3-(4-tert-Butylcarbamoyl-2-tert-butylsulfanylmethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester (0.46 mmol) was treated with lithium hydroxide in MeOH and H2O at 60° C. for 20 minutes to give the title compound.

Sources & evidence

ORD record
ord-ba75f414e8024e80ad5e2277fe66f919
Source dataset
uspto-grants-2011_12
Patent number
US08071807B2

Reaction notes

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