反应详情

12.0 g (0.052 mole) of 2-(2-hydroxyethyl)-pyrazolo-[1,5-c]quinazolin-5(6H)-one is taken up in pyridine (120 ml), cooled down to 0° and treated with 11.0 g (0.058 mole or 1.1 equivalent) of 98% tosyl chloride. The mixture is stirred for 4 hours, keeping the temperature below 20° during the reaction period, after which it is poured onto 1.8 l. of ice-water and stirred until solids form. The off-white precipitates are filtered off and dried in vacuo at 100° for 3 hours. Yield: 17.43 g, m.p. 194°-196°; 87.4% crude yield.

1. temperaturecooled down to 0°
2. customthe temperature below 20°
3. customduring the reaction period
4. additionafter which it is poured onto 1.8 l
5. customform
6. customThe off-white precipitates
7. filtrationare filtered off
8. customdried in vacuo at 100° for 3 hours