反应详情

1,1-dimethylethyl {1-[2-(7-fluoro-2-oxo-1(2H)-quinolinyl)ethyl]-4-piperidinyl}carbamate (1.32 g; 3.39 mmol) was dissolved in a mixture of chloroform (10 ml) and HCl (12 ml) and stirred at rt under argon for 1 h. The salts were then dissolved in MeOH and all solvents removed. The residues were redissolved in MeOH and stirred with amberlyst ion exchange resin until a neutral pH was reached. This was then filtered and the solvent removed. The crude residue was subjected to chromatography on silica gel using a 0-20% 2M NH3:MeOH/DCM gradient to provide the desired compound (632 mg; 64%)

1. customall solvents removed
2. dissolutionThe residues were redissolved in MeOH
3. stirringstirred with amberlyst ion exchange resin until a neutral pH
4. filtrationThis was then filtered
5. customthe solvent removed