反应详情

1,1-Dimethylethyl (1-{2-[7-(methyloxy)-2-oxo-1(2H)-quinolinyl]ethyl}-4-piperidinyl)carbamate (2.25 g; 5.61 mmol) was dissolved in a mixture of chloroform (20 ml) and HCl (15 ml) and stirred at rt under argon for 1 hour. The salts were dissolved in MeOH and a small amount of toluene added, all the solvents were then removed. The residues were redissolved in MeOH and stirred with amberlyst ion exchange resin until a neutral pH was reached. The resin was filtered off and the solvent removed and the crude residues were purified by column chromatography on silica gel using a 0-20% 2M NH3:MeOH/DCM gradient, to give the desired product (900 mg; 54%).

1. customall the solvents were then removed
2. dissolutionThe residues were redissolved in MeOH
3. stirringstirred with amberlyst ion exchange resin until a neutral pH
4. filtrationThe resin was filtered off
5. customthe solvent removed
6. customthe crude residues were purified by column chromatography on silica gel using a 0-20% 2M NH3