反应详情

温度

150 °C

8-Ethyl-7-fluoro-2-(2-propen-1-yloxy)-1,5-naphthyridine (0.660 g, 2.84 mmol) was dissolved in xylene (14 ml) at rt under argon, whereupon tetrakis(triphenylphosphine)palladium (0.329 g, 0.284 mmol) was added. The reaction was then heated to 150° C. for 30 mins. Reaction was then cooled, a solid then precipitated out which was filtered. The filtrate was then purified by column chromatography on silica gel eluting with 0-100% EtOAc in hexane then 0-20% MeOH in EtOAc gradient to give title compound as a white solid (0.181 g, 27%).

1. additionwas added
2. customReaction
3. temperaturewas then cooled
4. customa solid then precipitated out which
5. filtrationwas filtered
6. customThe filtrate was then purified by column chromatography on silica gel eluting with 0-100% EtOAc in hexane