反应详情

A mixture of methyl 6-(methyloxy)-1,5-naphthyridine-3-carboxylate (1.45 g, 6.65 mmol) in 30% HBr in acetic acid (40 ml) was stirred at rt for 18 h before evaporation and drying in vacuo. The solid was washed with Et2O and dried in vacuo to give the desired product as the dihydrobromide salt (2.425 g, 99%).

1. customdrying in vacuo
2. washThe solid was washed with Et2O
3. customdried in vacuo