HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl oxoacetate → 6,7-Difluoro-1,2-dihydroquinoxalin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl oxoacetate | HCID 70211 | — |
| Reactant | 1,2-Diamino-4,5-difluorobenzene | HCID 2736755 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 6,7-Difluoro-1,2-dihydroquinoxalin-2-one | HCID 6324339 | — |
Reaction Steps
A mixture of 4,5-difluoro-1,2-benzenediamine (0.60 g) and 50% ethyl glyoxalate in toluene (0.87 ml) in ethanol (25 ml) was heated under reflux for 2 hours then cooled. After refrigeration overnight, the resulting solid was collected and washed with ice-cold ethanol and dried under vacuum to give a solid (0.57 g; 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071592B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-7606aba2855d46779e36807cb9f09725 |
| Source note | uspto-grants-2011_12 |