反应详情

Trifluoroacetic acid (3 mL) was added to 4-[2,2-bis(methyloxy)ethyl]-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one (0.9 g, 3.4 mmol) in water (3 mL) at room temperature and stirred for 2 h. The reaction mixture was concentrated and the residue was purified by column chromatography (silica gel) using a 0-10% MeOH/DCM/1% NH4OH gradient to give the product as a mixture of aldehyde and hemiacetal (0.6 g, 80%).

1. concentrationThe reaction mixture was concentrated
2. customthe residue was purified by column chromatography (silica gel)
3. customto give the product