反应详情

温度

120 °C

To 6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbaldehyde (318 mg, 2.3 mmol) in Ac2O (3 mL) was added Et3N (1 mL). The reaction was heated at 120° C. for 18 hours. The reaction was concentrated and the resulting material was dissolved in MeOH and loaded onto silica gel and evaporated. Purification by column chromatography (silica gel) using a hexanes/ethyl acetate gradient (0-100% EtOAc) provided the desired product as a solid (80 mg, 30%). LCMS (ES+) m/z 162 (MH+).

1. concentrationThe reaction was concentrated
2. dissolutionthe resulting material was dissolved in MeOH
3. customevaporated
4. customPurification by column chromatography (silica gel)