反应详情

To a solution of ethyl 4-hydroxy-1-(phenylmethyl)-3-piperidinecarboxylate (30 g, 114.4 mmol) in THF/water (800 ml/80 mL) was added 2N sodium hydroxide solution (126 mL). The reaction mixture was stirred at room temperature for 5 h and then the pH was adjusted to 7 with 5N hydrochloric acid solution.