Hydrochloric Acid → HCID 20502081, compound

HRID 657174Notes

Reaction equation

HRID 657174 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:4][CH:3]1[C:15]([O:17]CC)=[O:16].[OH-].[Na+].Cl>C1COCC1.O>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:4][CH:3]1[C:15]([OH:17])=[O:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 563051HCID 563051, compound

Product 1

HCID 20502081HCID 20502081, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

To a solution of ethyl 4-hydroxy-1-(phenylmethyl)-3-piperidinecarboxylate (30 g, 114.4 mmol) in THF/water (800 ml/80 mL) was added 2N sodium hydroxide solution (126 mL). The reaction mixture was stirred at room temperature for 5 h and then the pH was adjusted to 7 with 5N hydrochloric acid solution.

Sources & evidence

ORD record
ord-da3304b4cfe94ea58ebc47533123cd56
Source dataset
uspto-grants-2011_12
Patent number
US08071592B2

Reaction notes

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