反应详情

To a mixture of 6,7-dimethoxy-4-piperidin-4-yl-quinazoline (5.18 g, 19.0 mmol), prepared as described in Example 1d, and (4-iodo-phenyl)-carbamic acid 4-nitro-phenyl ester (8.00 g, 20.8 mmol), prepared as described in the preceding step, in DCM (20 mL) was added DIEA (3.44 mL, 20.8 mmol) with stirring at rt. After stirring at rt for 5 min, CHCl3 (20 mL) was added to thin the slurry, and after stirring for 4 h at rt, the greenish mixture was washed with 0.1 M NaOH (208 mL), and the resulting precipitate in the organic layer was filtered. The filter cake was dissolved in 92:8 DCM/MeOH (250 mL) and washed with water (1×50 mL) and 0.1 M NaOH (1×200 mL). The organic layer was then dried (Na2SO4), concentrated under reduced pressure, and the resulting greyish solid was triturated with hot toluene (1×20 mL) and filtered. The filter cake was washed with toluene (2×20 mL) to provide, after drying of the filter cake, the title compound as an off-white solid (7.84 g, 80%). Nmr reveals a single ˜15 mol % impurity. A sample was purified to homogeneity by flash chromatography. 1H-NMR (300 MHz, CDCl3) 9.07 (s, 1H), 7.58 (m, 2H), 7.35 (s, 1H), 7.25 (s, 1H), 7.17 (m, 2H), 6.49 (br s, 1H), 4.32-4.22 (m, 2H), 4.07 (s, 3H), 4.06 (s, 3H), 3.60 (m, 1H), 3.24-3.11 (m, 2H), 2.23-2.07 (m, 2H), 2.05-1.94 (m, 2H). LC/MS (ESI): calcd mass 518.1, found 519.2 (MH)+.

1. customprepared
2. customprepared
3. stirringAfter stirring at rt for 5 min
4. stirringafter stirring for 4 h at rt
5. washthe greenish mixture was washed with 0.1 M NaOH (208 mL)
6. filtrationthe resulting precipitate in the organic layer was filtered
7. dissolutionThe filter cake was dissolved in 92:8 DCM/MeOH (250 mL)
8. washwashed with water (1×50 mL) and 0.1 M NaOH (1×200 mL)
9. dry with materialThe organic layer was then dried (Na2SO4)
10. concentrationconcentrated under reduced pressure
11. customthe resulting greyish solid was triturated with hot toluene (1×20 mL)
12. filtrationfiltered
13. washThe filter cake was washed with toluene (2×20 mL)
14. customto provide
15. customafter drying of the filter cake
16. customA sample was purified to homogeneity by flash chromatography