反应详情

温度

50 °C

To a suspension of 2-bromo-4-methylbenzoic acid (15.0 g, 69.8 mmol) in toluene (60 mL), thionyl chloride (10.3 mL) and DMF (0.10 mL) were added and stirred at 50° C. for 3 h. After cooling to room temperature, the excess thionyl chloride was removed in vacuo. The residue was dissolved in toluene (50 mL), and the mixture was added to the solution of ammonia (25%, 60 mL). The white precipitate was filtered over Celite and dried in vacuo to afford 2-bromo-4-methylbenzamide (14.8 g, 99%).

1. additionwere added
2. temperatureAfter cooling to room temperature
3. customthe excess thionyl chloride was removed in vacuo
4. dissolutionThe residue was dissolved in toluene (50 mL)
5. additionthe mixture was added to the solution of ammonia (25%, 60 mL)
6. filtrationThe white precipitate was filtered over Celite
7. customdried in vacuo