Methyl 3-(2,3-dichlorophenyl)propionate → 3-(2,3-Dichlorophenyl)propanoic acid

HRID 65732Notes

Reaction equation

HRID 65732 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]([O:13]C)=[O:12]>[OH-].[Na+]>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]([OH:13])=[O:12]

Participants

3

Reactant 1

HCID 12595092Methyl 3-(2,3-dichlorophenyl)propionate

Product 1

HCID 125951013-(2,3-Dichlorophenyl)propanoic acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Methyl 3-(2,3-dichlorophenyl)propionate was refluxed in 10% aqueous sodium hydroxide (1 l.) for two hours and the reaction mixture was cooled, acidified and filtered. The filter cake was dissolved in hot aqueous sodium bicarbonate, and filtered. The filtrate was acidified and filtered to yield 3-(2,3-dichlorophenyl)propionic acid.

Workup

  1. temperaturethe reaction mixture was cooled
  2. filtrationfiltered
  3. dissolutionThe filter cake was dissolved in hot aqueous sodium bicarbonate
  4. filtrationfiltered
  5. filtrationfiltered

Sources & evidence

ORD record
ord-000a1bced82f4a62a15526285accafb3
Source dataset
uspto-grants-1978_12
Patent number
US04128666

Reaction notes

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