反应详情

温度

50 °C

To a suspension of 3-bromo-5-(methyloxy)benzoic acid (9.6 g, 41.6 mmol) in toluene (60 mL) were added thionyl chloride (9.89 g, 83.1 mmol) and DMF (0.10 mL) and the mixture stirred at 50° C. for 4 h. The mixture was allowed to cool to room temperature, and then the excess thionyl chloride was removed in vacuo. The residue was dissolved in toluene (50 mL), and the mixture was added to a solution of ammonia (25%, 50 mL). A precipitate formed and was filtered off using Celite, and dried to afford 3-bromo-5-(methyloxy)benzamide (8.70 g, 90%).

1. temperatureto cool to room temperature
2. customthe excess thionyl chloride was removed in vacuo
3. dissolutionThe residue was dissolved in toluene (50 mL)
4. additionthe mixture was added to a solution of ammonia (25%, 50 mL)
5. customA precipitate formed
6. filtrationwas filtered off
7. customdried