Trimethylsilyl iodide → HCID 86761473, compound

HRID 657480Notes

Reaction equation

HRID 657480 reaction equation
[Na:1].N1(C2(OC[C@H](OCP(O)(O)=O)C2)O)C=C(C)C(=O)NC1=O.[O:23]=[CH:24][C@H:25]([C@@H:27]([CH2:29][OH:30])[OH:28])[OH:26].[N:31]1([C:39]2([O:56][CH2:55][C@H:42]([O:43][CH2:44][P:45]([O:51]C(C)C)([O:47]C(C)C)=[O:46])[CH2:41]2)[OH:40])[CH:38]=[CH:37][C:35]([NH2:36])=[N:34][C:32]1=[O:33].I[Si](C)(C)C>>[Na:1].[O:23]=[CH:24][C@H:25]([C@@H:27]([CH2:29][OH:30])[OH:28])[OH:26].[N:31]1([C:39]2([O:56][CH2:55][C@H:42]([O:43][CH2:44][P:45]([OH:47])([OH:51])=[O:46])[CH2:41]2)[OH:40])[CH:38]=[CH:37][C:35]([NH2:36])=[N:34][C:32]1=[O:33]

Participants

4

Reactant 3

HCID 85247Trimethylsilyl iodideHCID 86761458HCID 86761458, compoundHCID 86761475HCID 86761475, compound

Product 1

HCID 86761473HCID 86761473, compoundYield 73%

Procedure

This compound was prepared as described for 3f, using 22 (200 mg, 0.53 mmol) as a starting material and iodotrimethysilane (0.6 mL, 4.2 mmol). Compound 3h (130 mg, 0.38 mmol) was obtained as a colorless solid, in 73% yield, which was characterized as follows:

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-8fff611083844e4a9128a18d7b80cdd3
Source dataset
uspto-grants-2011_12
Patent number
US08076310B2

Reaction notes

Loading…