反应详情

温度

200 °C

500 mg of 4-(4-fluorophenyl)-4-methoxy-1-phenylcyclohexanecarbonitrile were dissolved in 30 ml of ethylene glycol and 272 mg of potassium hydroxide were added. The reaction mixture was subsequently stirred for 5 h at 200° C. After cooling, the reaction mixture was poured onto an ice/water mixture and extracted three times with MTB. The aqueous phase was acidified to pH=1 with 2 N hydrochloric acid. The precipitated crude product was filtered off with suction and dissolved in a little hot toluene. The crystals deposited during cooling were filtered off with suction and dried. 450 mg of the title compound were obtained as a white solid.

1. temperatureAfter cooling
2. extractionextracted three times with MTB
3. customThe precipitated crude product
4. filtrationwas filtered off with suction
5. dissolutiondissolved in a little hot toluene
6. temperatureduring cooling
7. filtrationwere filtered off with suction
8. customdried