Ethylene Glycol → 4-(4-Fluorophenyl)-4-methoxy-1-phenylcyclohexanecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

500 mg of 4-(4-fluorophenyl)-4-methoxy-1-phenylcyclohexanecarbonitrile were dissolved in 30 ml of ethylene glycol and 272 mg of potassium hydroxide were added. The reaction mixture was subsequently stirred for 5 h at 200° C. After cooling, the reaction mixture was poured onto an ice/water mixture and extracted three times with MTB. The aqueous phase was acidified to pH=1 with 2 N hydrochloric acid. The precipitated crude product was filtered off with suction and dissolved in a little hot toluene. The crystals deposited during cooling were filtered off with suction and dried. 450 mg of the title compound were obtained as a white solid.

Provenance & Evidence