Water → HCID 59442619, compound

Participants

Reaction Steps

5.7 g of 3-bromo-5-phenyl-1H-pyrazole were dissolved in 50 ml of anhydrous DMF, 0.74 g of sodium hydride and 4.1 g of bromomethylcyclopropane were added and the mixture was allowed to stand for 17 h at room temperature. The reaction mixture was then treated with 1 ml of water and the volatile constituents were removed in vacuo. Chromatography on reversed phase silica gel yielded 1.4 g of 3-bromo-1-cyclopropylmethyl-5-phenyl-1H-pyrazole and 2.7 g of 5-bromo-1-cyclopropylmethyl-3-phenyl-1H-pyrazole as viscous oils.

Provenance & Evidence