反应详情

8.5 g of 3-methylsulfanylbenzamide and 18 ml of dimethylformamide dimethyl acetal were heated at 120° C. while the formed methanol was eliminated by distillation. After heating for 3 h, the volatiles were removed in vacuo. The crude product was purified by flash chromatography (300 g silica gel; DCM/MOH, gradient from 100:0 to 95:5). 8 g of the title compound were obtained as an oil.

1. distillationwas eliminated by distillation
2. temperatureAfter heating for 3 h
3. customthe volatiles were removed in vacuo
4. customThe crude product was purified by flash chromatography (300 g silica gel; DCM/MOH, gradient from 100:0 to 95:5)