反应详情

温度

72 °C

(S)-3-Bromo-2-methylpropan-1-ol (6.2 g, 40 mmol) was dissolved in dry CH3CN (100 mL) and dry, pulverized K2CO3 (10.4 g, 75 mmol) was introduced followed by 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol (11.0 g, 50 mmol). The reaction mixture was heated at 72° C. for 20 h, cooled and filtered. The filtrate was evaporated to an oil, which was applied to a column of silica gel. Elution initially with hexanes, gradually increasing polarity to a mixture of hexanes/ethyl acetate (3:2) as eluent, provided the title compound (7.56 g, 64%) as an oil.

1. customdry
2. additionwas introduced
3. temperaturecooled
4. filtrationfiltered
5. customThe filtrate was evaporated to an oil, which
6. washElution initially with hexanes
7. temperaturegradually increasing polarity
8. additionto a mixture of hexanes/ethyl acetate (3:2) as eluent