HCID 68531843, compound → HCID 68529618, compound

HRID 657536Notes

Reaction equation

HRID 657536 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][CH:11]=1)[CH:8]([C:12]#[N:13])[CH2:7]2)[CH3:2]>CO.[Ni]>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][CH:11]=1)[CH:8]([CH2:12][NH2:13])[CH2:7]2)[CH3:2]

Participants

4

Reactant 1

HCID 68531843HCID 68531843, compound

Product 1

HCID 68529618HCID 68529618, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent2×

Procedure

1.5 g (8.65 mmoles) of the product of Step 1 are dissolved in 30 mL of methanol (MeOH). 30 mL of a (7N) ammoniacal methanol solution and 0.5 g of Raney nickel. The reaction mixture is then hydrogenated overnight under a pressure of 1 bar, at ambient temperature. The catalyst is then filtered off and the filtrate is evaporated to dryness. The expected product is obtained in the form an oil.

Workup

  1. customhydrogenated overnight
  2. customat ambient temperature
  3. filtrationThe catalyst is then filtered off
  4. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-baf9e527db564d128cf260c5ea7ec7ef
Source dataset
uspto-grants-2011_12
Patent number
US08076325B2

Reaction notes

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