HCID 68530103, compound → HCID 68527303, compound

HRID 657537Notes

Reaction equation

HRID 657537 reaction equation
[C:1]([O:5][C:6]1[CH:7]=[C:8]2[C:11](=[CH:12][CH:13]=1)[CH:10]([C:14]#[N:15])[CH2:9]2)([CH3:4])([CH3:3])[CH3:2]>CO.[Ni]>[C:1]([O:5][C:6]1[CH:7]=[C:8]2[C:11](=[CH:12][CH:13]=1)[CH:10]([CH2:14][NH2:15])[CH2:9]2)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 68530103HCID 68530103, compound

Product 1

HCID 68527303HCID 68527303, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent2×

Procedure

1.1 g (5.46 mmoles) of the product of Step 1 are dissolved in 30 mL of methanol (MeOH). 30 mL of (7N) ammoniacal methanol solution and 0.5 g of Raney nickel are added. The reaction mixture is hydrogenated overnight under a pressure of 1 bar, at ambient temperature. The catalyst is then filtered off and the filtrate is evaporated to dryness. The expected product is obtained in the form of an oil.

Workup

  1. filtrationThe catalyst is then filtered off
  2. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-2b721d735ed14834afd27d7f3534c4bb
Source dataset
uspto-grants-2011_12
Patent number
US08076325B2

Reaction notes

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