Tetrahydrofuran → HCID 68973270, compound

HRID 657557Notes

Reaction equation

HRID 657557 reaction equation
[ClH:1].CO[C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[CH:8]([CH2:14][N:15](C)[CH2:16][CH2:17][C:18]([N:20]1[CH2:26][CH2:25][C:24]3[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:23]=3[CH2:22][CH2:21]1)=[O:19])[CH2:7]2.C1C[O:39][CH2:38]C1>O1CCOCC1>[ClH:1].[CH3:13][O:12][C:11]1[C:10]([O:39][CH3:38])=[C:9]2[C:6]([CH2:7][CH:8]2[CH2:14][NH:15][CH2:16][CH2:17][C:18]([N:20]2[CH2:26][CH2:25][C:24]3[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:23]=3[CH2:22][CH2:21]2)=[O:19])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 68972400N-[(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxopropan-1amine hydrochloride

Product 1

HCID 68973270HCID 68973270, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Obtained in the same manner as the product of Example 1, but with replacement of the [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamine in Step 4 by the product of Preparation 1 and of the THF by dioxane.

Workup

  1. customwith replacement of the [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamine in Step 4 by the product of Preparation 1

Sources & evidence

ORD record
ord-e3849bab20e946e6af5fe05da345a5f7
Source dataset
uspto-grants-2011_12
Patent number
US08076325B2

Reaction notes

Loading…