1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine → N-[2-(5,6-Dimethoxy-2,3-dihydro-1H-inden-2-yl)ethyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxopropan-1-amine hydrochloride

HRID 657558Notes

Reaction equation

HRID 657558 reaction equation
[ClH:1].COC1C=C2C(=CC=1OC)C([CH2:14][N:15]([CH3:35])[CH2:16][CH2:17][C:18]([N:20]1[CH2:26][CH2:25][C:24]3[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:23]=3[CH2:22][CH2:21]1)=[O:19])C2.COC1C=C2C(=CC=1OC)C(CNC)C2.[CH3:51][O:52][C:53]1[CH:54]=[C:55]2[C:59](=[CH:60][C:61]=1[O:62][CH3:63])[CH2:58][CH:57]([CH2:64]CNC)[CH2:56]2>>[ClH:1].[CH3:63][O:62][C:61]1[CH:60]=[C:59]2[C:55](=[CH:54][C:53]=1[O:52][CH3:51])[CH2:56][CH:57]([CH2:64][CH2:14][N:15]([CH3:35])[CH2:16][CH2:17][C:18]([N:20]1[CH2:26][CH2:25][C:24]3[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:23]=3[CH2:22][CH2:21]1)=[O:19])[CH2:58]2

Participants

4

Reactant 3

HCID 222623581-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamineHCID 68533314[2-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)ethyl]methylamineHCID 68972400N-[(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxopropan-1amine hydrochloride

Product 1

HCID 68971773N-[2-(5,6-Dimethoxy-2,3-dihydro-1H-inden-2-yl)ethyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxopropan-1-amine hydrochloride

Procedure

Obtained in the same manner as the product of Example 1, but with replacement of the [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamine in Step 4 by [2-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)ethyl]methylamine.

Sources & evidence

ORD record
ord-f1116da1ba774c22903601e50a686593
Source dataset
uspto-grants-2011_12
Patent number
US08076325B2

Reaction notes

Loading…