反应详情

A mixture of (3S,5S)-1-(3-hydroxypropyl)-3,5-dimethylpiperidine (1.91 g), thionyle chloride (0.96 mL) and dichloromethane (10 mL) is stirred at room temperature for 5 h, concentrated under reduced pressure and triturated in diethyl oxide to give 2.0 g of (3S,5S)-1-(3-chloropropyl)-3,5-dimethylpiperidine, hydrochloride as a beige powder used without further purification.

1. concentrationconcentrated under reduced pressure
2. customtriturated in diethyl oxide