HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4'-(3-Chloropropoxy)biphenyl-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Bromo-3-chloropropanol | HCID 521181 | — |
| Reactant | 4'-Hydroxybiphenyl-1-carboxylic acid ethyl ester | HCID 68910550 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4'-(3-Chloropropoxy)biphenyl-1-carboxylic acid ethyl ester | HCID 68905724 | — |
Reaction Steps
Following the procedure described in example 47§D, but starting from 4′-hydroxybiphenyl-1-carboxylic acid ethyl ester (3 g), potassium carbonate (8.55 g) and 1-bromo-3-chloropropanol (6 mL) in N,N-dimethylformamide (30 mL) affords 4′-(3-chloropropoxy)biphenyl-1-carboxylic acid ethyl ester in quantitative yield used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076329B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-d77c3aa668a64328a9a03284c74e11a2 |
| Source note | uspto-grants-2011_12 |