反应详情

Following the procedure described in example 47§D, but starting from 4′-hydroxybiphenyl-1-carboxylic acid ethyl ester (3 g), potassium carbonate (8.55 g) and 1-bromo-3-chloropropanol (6 mL) in N,N-dimethylformamide (30 mL) affords 4′-(3-chloropropoxy)biphenyl-1-carboxylic acid ethyl ester in quantitative yield used without further purification.