反应详情

A solution of 4-(4-methoxyphenyl)pyridine (5.68 g) and metachloroperbenzoic acid (70%, 11.34 g) in chloroform is stirred for 2.5 hours at room temperature, concentrated under reduced pressure and purified by chromatography over silica gel (eluent dichloromethane/methanol from 100/0 to 90/10) to give 5.62 g of 4-(4-methoxyphenyl)pyridine 1-oxide used without further purification.

1. concentrationconcentrated under reduced pressure
2. custompurified by chromatography over silica gel (eluent dichloromethane/methanol from 100/0 to 90/10)