Hydrogen Bromide → 2-Chloro-4-(4-hydroxyphenyl)pyridine hydrobromide

HRID 657667Notes

Reaction equation

HRID 657667 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([O:14]C)=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1.[BrH:16]>>[BrH:16].[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([OH:14])=[CH:12][CH:13]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 534408782-Chloro-4-(4-methoxyphenyl)pyridine

Product 1

HCID 1363359722-Chloro-4-(4-hydroxyphenyl)pyridine hydrobromide

Procedure

A mixture of 2-chloro-4-(4-methoxyphenyl)pyridine (4.6 g) and 48% aqueous hydrobromic acid solution is heated under reflux for 3.5 hours and allowed to cool back to room temperature. The precipitate that appears is separated by filtration, washed with water and dried under reduced pressure to give 4.9 g of 2-chloro-4-(4-hydroxyphenyl)pyridine hydrobromide as a yellow solid used without further purification.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 3.5 hours
  3. customThe precipitate that appears is separated by filtration
  4. washwashed with water
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-8f8d494fbdab474f8a02b5649782bc73
Source dataset
uspto-grants-2011_12
Patent number
US08076329B2

Reaction notes

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