反应详情

A mixture of 2-chloro-4-(4-methoxyphenyl)pyridine (4.6 g) and 48% aqueous hydrobromic acid solution is heated under reflux for 3.5 hours and allowed to cool back to room temperature. The precipitate that appears is separated by filtration, washed with water and dried under reduced pressure to give 4.9 g of 2-chloro-4-(4-hydroxyphenyl)pyridine hydrobromide as a yellow solid used without further purification.

1. temperatureis heated
2. temperatureunder reflux for 3.5 hours
3. customThe precipitate that appears is separated by filtration
4. washwashed with water
5. customdried under reduced pressure