反应详情

To a solution of 2-cyano-5-cyclopropylpyridine (210 mg, 1.4 mmol) in 20 mL of 7.0 M ammonia in MeOH was added a small spoon of Raney Ni slurry. The mixture was hydrogenated at 50 psi overnight. The catalyst was filtered off and the filtrate was concentrated to yield a dark oil which was used for the next step reaction without further purification.

1. customwas hydrogenated at 50 psi overnight
2. filtrationThe catalyst was filtered off
3. concentrationthe filtrate was concentrated
4. customto yield a dark oil which
5. customwas used for the next step reaction without further purification