5-Cyclopropylpicolinonitrile → (5-Cyclopropylpyridin-2-yl)methanamine

Participants

Reaction Steps

To a solution of 2-cyano-5-cyclopropylpyridine (210 mg, 1.4 mmol) in 20 mL of 7.0 M ammonia in MeOH was added a small spoon of Raney Ni slurry. The mixture was hydrogenated at 50 psi overnight. The catalyst was filtered off and the filtrate was concentrated to yield a dark oil which was used for the next step reaction without further purification.

Provenance & Evidence