HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Azido-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-ol → 3-Amino-3-[6-(trifluoromethyl)pyridin-3-yl]propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Azido-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-ol | HCID 58103594 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Amino-3-[6-(trifluoromethyl)pyridin-3-yl]propan-1-ol | HCID 58103588 | — |
Reaction Steps
A mixture of 3-azido-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-ol (7.29 g, 29.6 mmol), ethyl acetate (320 mL), and 10% Pd—C (3.2 g) was stirred under H2 (1 atm) overnight. The catalyst was filtered off and the filtrate was concentrated in vacuo to yield the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076345B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-03d56437c0604084be8359c3fd78050f |
| Source note | uspto-grants-2011_12 |