Hydrochloric Acid → HCID 58103591, compound

HRID 657767Notes

Reaction equation

HRID 657767 reaction equation
[CH:1]1([C@H:4]([C:12]2[CH:13]=[N:14][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:17]=2)[NH:5][S@](C(C)(C)C)=O)[CH2:3][CH2:2]1.C(O)C.Cl.O1CCOCC1>>[CH:1]1([C@@H:4]([C:12]2[CH:13]=[N:14][C:15]([C:18]([F:21])([F:19])[F:20])=[CH:16][CH:17]=2)[NH2:5])[CH2:3][CH2:2]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 312751,4-DioxaneHCID 66871736HCID 66871736, compound

Product 1

HCID 58103591HCID 58103591, compound

Procedure

(S)—N—((R)-cyclopropyl(6-(trifluoromethyl)pyridin-3-yl)methyl)-2-methylpropane-2-sulfinamide (0.245 g, 0.000765 mol), ethanol (2.7 g, 0.059 mol), and 4.0 M of hydrogen chloride in dioxane (2.7 mL, 0.011 mol) are combined and stirred for 30 minutes. The mixture is allowed to stir overnight. The solvent is removed and the residue is dissolved in ethanol. After washing with ethanol for 3 times, the mixture is concentrated and the residue is dried under high vacuum overnight to obtain the title compound.

Workup

  1. stirringto stir overnight
  2. customThe solvent is removed
  3. dissolutionthe residue is dissolved in ethanol
  4. washAfter washing with ethanol for 3 times
  5. concentrationthe mixture is concentrated
  6. customthe residue is dried under high vacuum overnight

Sources & evidence

ORD record
ord-8a48fc39ebcc4c6ab1209d7a9eb83c98
Source dataset
uspto-grants-2011_12
Patent number
US08076345B2

Reaction notes

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