反应详情

A reaction mixture of 5-chloro-2-(4-chloro-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile (80 mg, 0.26 mmol) and (3-(4H-1,2,4-triazol-4-yl)phenyl)methanamine (120 mg, 0.40 mmol) in acetonitrile (1 mL) and N,N-diisopropylethylamine (0.6 mL, 4 mmol) was subjected to microwave irradiation at 185° C. for 2.5 h. The reaction mixture was concentrated and purified by semi-preparative HPLC (100×20.2 mm, C18 column; 30-50% CH3CN-water [10 mM Et2NH]) to yield a light yellow solid.

1. customirradiation at 185° C. for 2.5 h
2. concentrationThe reaction mixture was concentrated
3. custompurified by semi-preparative HPLC (100×20.2 mm, C18 column; 30-50% CH3CN-water [10 mM Et2NH])
4. customto yield a light yellow solid