Water → HCID 58045790, compound

Participants

Reaction Conditions

Reaction Steps

6-Chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W2.006a, 500 mg) were initially charged in pyrrolidine (5 ml) at RT while stirring. Then the mixture was heated to 65° C. for 4 h. Thereafter, the pyrrolidine was drawn off, and the residue was taken up with water and extracted three times with dichloromethane. The combined organic phases were dried over sodium sulfate, filtered and concentrated. 438 mg of the title compound were obtained.

Provenance & Evidence