Water → HCID 58045790, compound

HRID 657876Notes

Reaction equation

HRID 657876 reaction equation
Cl[C:2]1[C:3]([CH3:13])=[C:4]([CH3:12])[C:5]2[N:6]([C:8]([NH2:11])=[N:9][N:10]=2)[N:7]=1.O.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH3:13][C:3]1[C:2]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[N:7][N:6]2[C:8]([NH2:11])=[N:9][N:10]=[C:5]2[C:4]=1[CH3:12]

Participants

4

Reactant 3

HCID 962WaterHCID 31268Pyrrolidine2×HCID 580458046-Chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-B]pyridazin-3-amine

Product 1

HCID 58045790HCID 58045790, compound

Conditions

Temperature
65 °C

Procedure

6-Chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W2.006a, 500 mg) were initially charged in pyrrolidine (5 ml) at RT while stirring. Then the mixture was heated to 65° C. for 4 h. Thereafter, the pyrrolidine was drawn off, and the residue was taken up with water and extracted three times with dichloromethane. The combined organic phases were dried over sodium sulfate, filtered and concentrated. 438 mg of the title compound were obtained.

Workup

  1. extractionextracted three times with dichloromethane
  2. dry with materialThe combined organic phases were dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-10501b93959a4bfaa8df3a395b2daf45
Source dataset
uspto-grants-2011_12
Patent number
US08076336B2

Reaction notes

Loading…