Dichloromethane → Diisopropylethylamine

Participants

Reaction Steps

The compound of formula (XIV) is reacted with a chlorinating agent, such as thionyl chloride, phosphorus oxychloride, and the like, optionally with a base, such as pyridine, and the like, in an organic solvent, such as toluene, benzene, chloroform, methylene chloride, and the like, in a temperature range of 0° C. to 80° C., preferably in the range of 25° C. to 60° C., to yield the corresponding compound of formula (XV). Alternatively, compound of formula (XV) is reacted with a chlorinating agent, such as mesyl chloride, and the like, with a base, such as triethylamine, diisopropylethylamine, and the like, in an organic solvent, such as THF, dichloromethane, chloroform, and the like, in a temperature range of 0° C. to 60° C., preferably in the range of 25° C. to 40° C., to yield the corresponding compound of formula (XV).

Provenance & Evidence