Dichloromethane → Diisopropylethylamine
Reaction equation
S(Cl)(C)(=O)=O.C([N:8]([CH2:11][CH3:12])[CH2:9][CH3:10])C.[CH2:13]1[CH2:17]OC[CH2:14]1.Cl[CH2:19]Cl>C(Cl)(Cl)Cl>[CH:11]([N:8]([CH:13]([CH3:17])[CH3:14])[CH2:9][CH3:10])([CH3:12])[CH3:19]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
The compound of formula (XIV) is reacted with a chlorinating agent, such as thionyl chloride, phosphorus oxychloride, and the like, optionally with a base, such as pyridine, and the like, in an organic solvent, such as toluene, benzene, chloroform, methylene chloride, and the like, in a temperature range of 0° C. to 80° C., preferably in the range of 25° C. to 60° C., to yield the corresponding compound of formula (XV). Alternatively, compound of formula (XV) is reacted with a chlorinating agent, such as mesyl chloride, and the like, with a base, such as triethylamine, diisopropylethylamine, and the like, in an organic solvent, such as THF, dichloromethane, chloroform, and the like, in a temperature range of 0° C. to 60° C., preferably in the range of 25° C. to 40° C., to yield the corresponding compound of formula (XV).
Sources & evidence
- ORD record
- ord-44f15d13f1b64931ae0c847c08bddf6f
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08076358B2
Reaction notes
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