反应详情

3-[1,3]Dioxan-2-yl-benzenethiol (2.57 g, 14.02 mmol), prepared as described in Example 1, Step C, (4,5-difluoro-2-nitro-phenyl)-methanol (2.65 g, 14.02 mmol), and cesium carbonate (9.1 g, 28 mmol) were combined in DMF (100 mL). The resulting mixture was stirred overnight at room temperature. Water was added, and the resulting mixture was then extracted with ethyl acetate. The organic layer was dried with Na2SO4 and filtered, and the solvent was removed to yield an oil, which was purified via silica column chromatography (50% EtOAc/heptane) to yield a solid.

1. extractionthe resulting mixture was then extracted with ethyl acetate
2. dry with materialThe organic layer was dried with Na2SO4
3. filtrationfiltered
4. customthe solvent was removed
5. customto yield an oil, which
6. customwas purified via silica column chromatography (50% EtOAc/heptane)
7. customto yield a solid