Dichloromethane → HCID 178484382, compound

HRID 658120Notes

Reaction equation

HRID 658120 reaction equation
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[OH-].[Na+].C(Cl)Cl>C(O)C>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 14219Metformin HydrochlorideHCID 14798Sodium Hydroxide

Product 1

HCID 178484382HCID 178484382, compoundYield 83.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.0 g of metformin hydrochloride and 2.40 g of sodium hydroxide were stirred in 100 ml of ethylalcohol at a temperature of 70° C., and then methylene chloride was added thereto. The produced inorganic salt was filtered, and ethyl acetate was added thereto, thus preparing metformin free-base. The produced crystal was filtered and dried in hot air, thus obtaining 6.50 g (yield: 83.4%) of metformin free-base.

Workup

  1. filtrationThe produced inorganic salt was filtered
  2. additionethyl acetate was added
  3. customthus preparing metformin free-base
  4. filtrationThe produced crystal was filtered
  5. customdried in hot air

Sources & evidence

ORD record
ord-083a63abb281477785791834e99e1fd2
Source dataset
uspto-grants-2011_12
Patent number
US08076377B2

Reaction notes

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