HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 178484382, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Metformin Hydrochloride | HCID 14219 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178484382 | HCID 178484382 | 83.4% |
Reaction Steps
10.0 g of metformin hydrochloride and 2.40 g of sodium hydroxide were stirred in 100 ml of ethylalcohol at a temperature of 70° C., and then methylene chloride was added thereto. The produced inorganic salt was filtered, and ethyl acetate was added thereto, thus preparing metformin free-base. The produced crystal was filtered and dried in hot air, thus obtaining 6.50 g (yield: 83.4%) of metformin free-base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076377B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-083a63abb281477785791834e99e1fd2 |
| Source note | uspto-grants-2011_12 |