Glutaric Acid → HCID 178484388, compound

HRID 658122Notes

Reaction equation

HRID 658122 reaction equation
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[OH-].[Na+].[C:12]([OH:20])(=[O:19])[CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17].C(Cl)Cl>C(O)C>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:12]([O-:20])(=[O:19])[CH2:13][CH2:14][CH2:15][C:16]([O-:18])=[O:17]

Participants

6

Reactant 4

HCID 743Glutaric AcidHCID 6344DichloromethaneHCID 14798Sodium HydroxideHCID 178484382HCID 178484382, compound

Product 1

HCID 178484388HCID 178484388, compoundYield 86.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.0 g of metformin, 2.40 g of sodium hydroxide and 3.98 g of glutaric acid were stirred in 150 ml of ethyl alcohol at a temperature of 70° C., and then methylene chloride was added thereto. The produced inorganic salt was filtered and ethyl acetate was added to the filtered solution. The produced crystal was filtered and dried in hot air, thus obtaining 6.79 g (yield: 57.7%) of metformin glutarate.

Workup

  1. filtrationThe produced inorganic salt was filtered
  2. additionethyl acetate was added to the filtered solution
  3. filtrationThe produced crystal was filtered
  4. customdried in hot air

Sources & evidence

ORD record
ord-ecf0fa3b2337412185e3c44166b38cbb
Source dataset
uspto-grants-2011_12
Patent number
US08076377B2

Reaction notes

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