Glutaric Acid → HCID 178484388, compound

HRID 658125Notes

Reaction equation

HRID 658125 reaction equation
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:10]([OH:18])(=[O:17])[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15]>C(O)C>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:10]([O-:18])(=[O:17])[CH2:11][CH2:12][CH2:13][C:14]([O-:16])=[O:15]

Participants

4

Reactant 2

HCID 743Glutaric AcidHCID 178484382HCID 178484382, compound

Product 1

HCID 178484388HCID 178484388, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
10 °C

Procedure

9.75 g (2.5 molar equivalents) of metformin free-base was stirred in 100 ml of ethanol at room temperature, after which a solution of 3.98 g (1 molar equivalent) of glutaric acid in ethanol was added dropwise thereto and stirred at 10° C. The produced crystal was filtered and dried in hot air, thus obtaining 7.41 g (yield: 62.8%) of metformin glutarate.

Workup

  1. filtrationThe produced crystal was filtered
  2. customdried in hot air

Sources & evidence

ORD record
ord-09d290427ad24818acec574a57285988
Source dataset
uspto-grants-2011_12
Patent number
US08076377B2

Reaction notes

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