Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Glutaric Acid | HCID 743 | — |
| Reactant | HCID 178484382 | HCID 178484382 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178484388 | HCID 178484388 | 94.9% |
Reaction Steps
9.75 g (2.5 molar equivalents) of metformin free-base was stirred in 100 ml of ethanol at room temperature, after which a solution of 3.98 g (1 molar equivalent) of glutaric acid in ethanol was added dropwise thereto and stirred at 10° C. The produced crystal was filtered and dried in hot air, thus obtaining 7.41 g (yield: 62.8%) of metformin glutarate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08076377B2 |
|---|
| Source dataset | uspto-grants-2011_12 |
|---|
| ORD ID | ord-09d290427ad24818acec574a57285988 |
|---|
| Source note | uspto-grants-2011_12 |
|---|
