Acetone → HCID 178484387, compound

HRID 658130Notes

Reaction equation

HRID 658130 reaction equation
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].CC(C)=O.O.[C:15]([OH:24])(=[O:23])[CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21]>CC(C)=O.O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:15]([O-:24])(=[O:23])[CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O-:22])=[O:21]

Participants

6

Reactant 4

HCID 180AcetoneHCID 196Adipic AcidHCID 962WaterHCID 178484382HCID 178484382, compound

Product 1

HCID 178484387HCID 178484387, compoundYield 139.1%

Reagents, catalysts & solvents 1

HCID 18366337Propan-2-one--water (1/1)Solvent

Procedure

9.75 g (2.5 molar equivalents) of the metformin free-base was stirred in a mixed solution of 112.5 ml of acetone and 5 ml of water at 40° C., and then a solution of 4.41 g (1 molar equivalent) of adipic acid in acetone-water was added dropwise thereto and stirred at room temperature. The produced crystal was filtered and dried in hot air, thus obtaining 11.47 g (yield: 93.9%) of metformin adipate.

Workup

  1. filtrationThe produced crystal was filtered
  2. customdried in hot air

Sources & evidence

ORD record
ord-32dd3154bafb40d9bc0434245d9870a9
Source dataset
uspto-grants-2011_12
Patent number
US08076377B2

Reaction notes

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