HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → HCID 178484387, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Adipic Acid | HCID 196 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 178484382 | HCID 178484382 | — |
| Solvent | Propan-2-one--water (1/1) | HCID 18366337 | — |
| Product | HCID 178484387 | HCID 178484387 | 139.1% |
Reaction Steps
9.75 g (2.5 molar equivalents) of the metformin free-base was stirred in a mixed solution of 112.5 ml of acetone and 5 ml of water at 40° C., and then a solution of 4.41 g (1 molar equivalent) of adipic acid in acetone-water was added dropwise thereto and stirred at room temperature. The produced crystal was filtered and dried in hot air, thus obtaining 11.47 g (yield: 93.9%) of metformin adipate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076377B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-32dd3154bafb40d9bc0434245d9870a9 |
| Source note | uspto-grants-2011_12 |