反应详情

12.5 g (2.5 molar equivalents) of metformin hydrochloride, 3.02 g (2.5 molar equivalents) of sodium hydroxide and 4.05 g (1 molar equivalent) of malic acid were stirred in a mixed solution of methanol and ethanol (1:1) at 40° C., and then the produced crystal was filtered. The produced crystal was stirred in ethanol at 50, and the stirred at 10° C. for 5 hours. Then, the crystal was filtered and dried in hot air, thus obtaining 8.94 g (yield: 75.4%) of metformin malate.

1. filtrationthe produced crystal was filtered
2. stirringthe stirred at 10° C. for 5 hours
3. filtrationThen, the crystal was filtered
4. customdried in hot air