[1,1'-Biphenyl]-4-ol, 4'-(1,1-dimethylethyl)- → racemic 3-{4-[1-(4'-tert-Butyl-biphenyl-4-yloxymethyl)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acid
Reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C[O:19][C:20](=[O:42])[CH2:21][CH2:22][NH:23][C:24](=[O:41])[C:25]1[CH:30]=[CH:29][C:28]([CH:31]([CH2:39]O)[CH2:32][CH2:33][CH2:34][C:35]([F:38])([F:37])[F:36])=[CH:27][CH:26]=1>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:39][CH:31]([C:28]3[CH:29]=[CH:30][C:25]([C:24]([NH:23][CH2:22][CH2:21][C:20]([OH:42])=[O:19])=[O:41])=[CH:26][CH:27]=3)[CH2:32][CH2:33][CH2:34][C:35]([F:36])([F:38])[F:37])=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]Participants
3
Procedure
The title compound is prepared by essentially following the procedures as described in Example 8, using 4′-tert-butyl-biphenyl-4-ol and 3-[4-(5,5,5-trifluoro-1-hydroxymethyl-pentyl)-benzoylamino]-propionic acid methyl ester as starting materials. MS (ES): 554.2 [M+H]−.
Sources & evidence
- ORD record
- ord-094c995c604b4de08db0a9cd4f7eeed4
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08076374B2
Reaction notes
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