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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 658314Generated: October 30, 2026

[1,1'-Biphenyl]-4-ol, 4'-(1,1-dimethylethyl)- → racemic 3-{4-[1-(4'-tert-Butyl-biphenyl-4-yloxymethyl)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acid

https://huagongshe.com/reaction/658314

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[1,1'-Biphenyl]-4-ol, 4'-(1,1-dimethylethyl)-HCID 88262—
Reactant3-[4-(5,5,5-Trifluoro-1-hydroxymethyl-pentyl)-benzoylamino]-propionic acid methyl esterHCID 67485530—
Productracemic 3-{4-[1-(4'-tert-Butyl-biphenyl-4-yloxymethyl)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acidHCID 24765239—

Reaction Steps

The title compound is prepared by essentially following the procedures as described in Example 8, using 4′-tert-butyl-biphenyl-4-ol and 3-[4-(5,5,5-trifluoro-1-hydroxymethyl-pentyl)-benzoylamino]-propionic acid methyl ester as starting materials. MS (ES): 554.2 [M+H]−.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08076374B2
Source datasetuspto-grants-2011_12
ORD IDord-094c995c604b4de08db0a9cd4f7eeed4
Source noteuspto-grants-2011_12